After fully adjusting for confounding covariates including age, sex, race, smoking, diabetes, hypertension, SBP, DBP, TC, fibrinogen, CRP, creatinine, UA, BUN, HbA1c, BMI, TG, HDL-C and FPG, whether as a continuous variable or classified variable, the higher METS-IR was independently related to the higher risk of SC-MI [as a classified variable, Q4 vs Q1, OR (95% CI): 1.395 (1.147, 1.698), P = 0.001, P for trend < 0.001; as a continuous variable, per 10-unit increment, OR (95% CI): 1.869 (1.524, 2.292), P < 0.001]. Here, CRP is linked to diabetes mellitus.