TGFB1 and bone fracture: Although adding bFGF to the healing process may raise safety concerns, several studies have shown that the addition of growth factors, including bFGF, IFG-I, and TGF-β1, to the treatment of bone fractures enhanced the healing process while having an excellent safety profile (Schmidmaier et al., 2004; Kawaguchi et al., 2007).