ACE2 and COVID-19: As binding of virus spike protein with ACE2 is the crucial step for viral entry into the host cell, this interaction can be targeted to develop potent therapeutics against COVID-19.16–18 Thus, designing potential therapeutics to inhibit SARS-CoV-2 RBD/ACE2 protein–protein interaction (PPI) has been the point of interest for many researchers, as it is the first line of approach to inhibit viral entry.