Given that EMC10 is a ubiquitously expressed gene and knockout mouse (emc10−/−) models showed decreased bone mineral content (https://www.mousephenotype.org/data/genes/MGI:1916933),21 the hyperparathyroidism together with osteoporosis and nephrocalcinosis observed in F2:S1, F2:S2, and the three previously reported cases might be linked to dysfunctional EMC10 presentation. The gene discussed is EMC10; the disease is osteoporosis.