In agreement with this, some meta-analyses have reported that administration of clinically effective antidepressant drugs, such as selective serotonin reuptake inhibitors, selective noradrenaline reuptake inhibitors, and tricyclic antidepressants drugs, decrease the pro-inflammatory cytokine levels (IL-1β, IL-6, and TNFα) in patients diagnosed with major depression disorder [94,95,96]. Here, IL1B is linked to major depressive disorder.