AKT1 and melanoma: For instance, quercetin (10–40 μM) in a dose-dependent manner inhibited PI3K/Akt and MAPK signaling pathway in UVB-irradiated B16F10 melanoma cells [96], whereas kaempferol targeting mTOR/PI3K/AKT/ pathway leading to cell cycle arrest in G2/M phase, apoptosis and inhibition of cell migration [97].