AKT1 and Familial prostate cancer: For example, matrine can improve the sensitivity of resistant cancer cells to chemotherapeutic drugs by reactivating apoptosis and inhibiting drug efflux [26]; Tetrandrine can fight the multiple-drug resistance (MDR) of cancer cells by downregulating the expression of ABCB1 transporters [27]; quercetin can reverse the resistance of paclitaxel-resistant prostate cancer cells in vitro by reversing activation of the androgen receptor and PI3K/Akt signaling [28].