In HCC treatment, curcumin enhanced the chemosensitivity of HCC cells to 5-FU in vitro, increased the apoptosis rate, arrested the cell cycle in the G2/M phase, and blocked PI3k/AKT/mTOR signaling by inhibiting the phosphorylation of PI3k and its downstream protein kinase. Here, MTOR is linked to hepatocellular carcinoma.