Among the numerous targets of Notch are proteins that play a key role in tumor development and progression, such as the hairy and enhance of split (HES) family, hairy/enhancer of spit related with YRPW motif (HEY), nuclear factor-kappa B (NF-κB), VEGF, mTOR, cyclin D1, c-myc, p21, p27, and Akt [103]. The gene discussed is AKT1; the disease is neoplasm.