Osthole reverses the chemotherapeutic resistance of cisplatin-resistant cervical cancer cells by inactivating the PI3K/AKT pathway [29]; and ginsenoside Rg3 can inhibit the mTOR signaling axis of SOX2, PI3K/Akt, and miR-429 to reduce the resistance to cisplatin [30]. The gene discussed is AKT1; the disease is cervical cancer.