GSK3α (glycogen synthase kinase 3 alpha), a key gene in pancreatic carcinoma, is upregulated by KRAS, which leads GSK3α to interact with transforming growth factor-beta activated kinase 1 (TAK1), activating IκB kinase complex (IKK), modulating NF-κB. Here, GSK3A is linked to exocrine pancreatic carcinoma.