Altogether, the genetic profile of PDAC cells with the important influence of tumor microenvironment impacts in several oncogenic signaling pathways, such as RAS/mitogen-activated protein kinase (MAPK) cascade, nuclear factor-kB (NF-κB), phosphoinsotide-3 kinase (PI3K), Jun N-terminal kinase (JNK), transforming growth factor β (TGF-β), WNT-Notch and Hedgehog (HH) among others [20,21]. The gene discussed is MAPK8; the disease is neoplasm.