CASP3 and hepatocellular carcinoma: Cheng et al. [72] reported that mulberry water extract had cytotoxic ability against a human liver cancer cell line (HepG2) and a human hepatocellular carcinoma cell line (Hep3B) via the activation of caspase-3, -9, and -8 and the downregulation in Bcl-2 via apoptotic-mediated pathways.