The same applies to a study performed by Hrudka et al., in which immunohistochemical staining for the transcription factor FOXF1 proved to be quite specific (87%), but only in the distinction of peripheral intrahepatic cholangiocarcinoma versus hilar/extrahepatic cholangiocarcinoma and metastatic PDAC [31]. Here, FOXF1 is linked to intrahepatic cholangiocarcinoma.