CASP3 and cancer: The anti-cancer property of (−)-anonaine on HeLa cells may be linked with induced nitric oxide and ROS, loss of mitochondrial membrane potential, activation of caspase 3, 7, 8, and 9, as well as increased expression of apoptosis-related proteins (including Bax, Bcl-2, and p53), and increased poly (ADP-ribose) polymerase cleavage [61].