In rat hepatocytes, the UPR signaling molecule involved in the proapoptotic actions of diclofenac was the CHOP protein [21], but in the Huh7 hepatoma cells the drug also reduced the expression of ATF6 and evoked phosphorylation of eIF2alpha, a protein directly activated by PERK [22]. The gene discussed is EIF2AK3; the disease is hepatocellular carcinoma.