HIF1A and B-cell chronic lymphocytic leukemia: Valsecchi et al. treated CLL with EZN-2208 and found that EZN-2208 can significantly inhibit the expression of HIF-1α, thereby impairing the directed chemotaxis of CXCL 12 in CLL cells, and induce cell death and prolong the survival time of mice with significant anti-leukemia activity [82,89,90].