TP53 and chronic myelogenous leukemia, BCR-ABL1 positive: Zhang et al. [84] found that deficiency of HIF-1α in chronic myeloid leukemia (CML) resulted in increased expression of the cell cycle inhibitors (p16InK4a, p19Arf, and p57) and the apoptosis gene (p53) in leukemia stem cells (LSC).