The possible mechanisms of action include inhibiting the accumulation of superoxide dismutase (SOD) and reactive oxygen species (ROS), increasing the expressions of p53 and p21, and promoting the growth of cells in G2/M-phase cell cycle arrest, etc., thereby inhibiting the levels of HIF-1α, microtubules and tumor angiogenesis [91]. The gene discussed is HIF1A; the disease is neoplasm.