Zhang et al. [84] found that deficiency of HIF-1α in chronic myeloid leukemia (CML) resulted in increased expression of the cell cycle inhibitors (p16InK4a, p19Arf, and p57) and the apoptosis gene (p53) in leukemia stem cells (LSC). This evidence concerns the gene CDKN2A and chronic myelogenous leukemia, BCR-ABL1 positive.