In vivo, the BITC-mediated downregulation of proteins involved in mitochondrial dynamics regulation was discovered in the mammary tumors of MMTV-neu mice fed a 3 mol BITC/kg diet, and BITC oral administration increased the expression of pro-apoptotic proteins caspase-3 and Bax development in GBM 8401 tumor-bearing nude mice [293]. Here, BAX is linked to breast cancer.