NOS3 and cardiac hypertrophy: The opening of the KATP channel demonstrated cardioprotective effects in cardiomyocytes, as well as increased secretion of atrial natriuretic peptide, cardiac hypertrophy, apoptosis, oxidative stress, inflammation suppression, and the endothelial nitric oxide synthase nitric oxide (NOSNO) signaling pathway, have all been identified as beneficial effects of the medicinal herbs [17].