Significantly increased the memory-related learning ability of the AD model rats with reductions in the levels of corticohippocampal Aβ1-40-burden and Aβ1-40-oligomers, and increased the levels of brain cognition and memory-related proteins, including BDNF, TrKB, PSD-95 and SNAP-25. Here, BDNF is linked to Alzheimer disease.