However, there is evidence from other clinical conditions such as patients with rheumatoid arthritis that in an environment of chronically elevated levels of inflammation ANXA1 protein levels are suppressed compared to controls [41] and that ANXA1 response to exogenous glucocorticoids is reduced, suggesting that under certain conditions the normal regulation of ANXA1 by glucocorticoids may be disrupted. This evidence concerns the gene ANXA1 and rheumatoid arthritis.