PCSK9 and hyperlipidemia: Finally, since we identified direct effects of alterations in the lipid metabolism on the prevalence of both allergy types, we assessed selected hyperlipidaemia-associated variations of the LDL-R, VLDL-R, apoB, and PCSK9 gene in relation to allergy occurrence using BMI- and hyperlipidaemia-adjusted binomial logistic regression.