Recently, an overexpression of the pituitary tumor-transforming gene 1 (PTTG1) and its transcriptional target matrix-metalloproteinase-2 have been reported in TCAM-2 and SEM-1 cells, suggesting that PTTG1 might play a role in the invasiveness and metastasis of cancer cells [39]. This evidence concerns the gene PTTG1 and cancer.