TNF and cancer: CAC-associated lipolysis was stimulated by exposing 3T3-L1 adipocytes to (1) established human pancreatic cancer cell lines, a cancer type highly associated with CAC, using CCM and co-culture (PANC-1 and AsPC-1, respectively); and (2) lipolytic CAC-associated cytokines TNF-α and IL-6 [1].