Other brown adipocyte markers, Cidea and Pgc1α, increased their expression in HF-fed animals, regardless of the suckling treatment, while Fndc5 and Prdm16 only presented greater gene expression levels in the HF-Leptin and HF-Celastrol, and in the HF-Lep+Cel group, respectively (U Mann–Whitney p < 0.05). The gene discussed is PRDM16; the disease is hydrops fetalis.