SOCS3 and hydrops fetalis: Regarding leptin-signaling-related genes, in rWAT (Figure 4), Lep mRNA expression increased in the HF-Lep+Cel group and Socs3 in the HF-Celastrol and HF-Lep+Cel groups, while Stat3 expression decreased in the HF-Leptin group (U Mann–Whitney p < 0.05).