That is, isocaloric intake of a fat-rich diet induced an adaptive response that was evidenced as a decreased expression in both tissues of the key lipogenic Fasn gene in all the HF-groups, regardless of treatment received during suckling, and decreased expression of Srebp1a in the HF-Leptin, HF-Cel, and HF-Cel+Lep groups only in the rWAT (U Mann–Whitney, p < 0.05). Here, SREBF1 is linked to hydrops fetalis.