ATF4 and metabolic dysfunction-associated steatohepatitis: Notably, the expression of Nnmtcan be regulated by the unfolded protein responses (UPR)-related protein kinase R-like endoplasmic reticulum kinase (PERK)-activating transcription factor 4 (ATF4) signaling in the context of either alcohol/palmitate-induced liver damage [9,10], or carbon tetrachloride-induced NASH [11].