In rats subjected to four-week iodine therapy, a comparative assessment of breast cancer tissue in the treatment group showed less vascular tissue, lower levels of tumor proliferation nuclear antigen (PNCA), lower levels of vascular endothelial growth factor (VEGF), lower levels of urokinase plasminogen activator (u-PA), and lower levels of peroxisome alpha proliferator-activated receptors (PPARα) than in the control group [111]. Here, PLAU is linked to breast cancer.