Reduction of EAAT1 expression observed in our study allows one to assume that the previously considered theory of insulin resistance could still be possible, as it is suggested that insulin-dependent down-regulation of EAAT1 is involved in the adjustment of Glu concentrations in synapses [68]; furthermore, EAAT1-mediated Glu transport is more efficient in Müller glial cells in diabetic patients [69]. Here, SLC1A3 is linked to Insulin resistance.