Our results demonstrate that as treatment progresses, the xfR5-D+T NP treated population could significantly increase the CM sub-population and boost TM and EM sub-population (Supplementary Figure S6); however, during active HIV infection, targeted treatment using xfR5-D+T NP or naïve xfR5 mAb maintained high E and aCTL sub-population to counter HIV infection. The gene discussed is ACAT2; the disease is HIV infectious disease.