When we examined the vascular density around the optic nerve, we found that when we compared the FH+ ApoE ɛ4+ HCL- group with: (i) FH- ApoE ɛ4- HCL+, the second group showed statistically significantly lower vascular density in the C2H11 and C3H11 (p < 0.05, in both cases); (ii) FH+ ApoE ɛ4- HCL-, the second group showed statistically significantly lower vascular density in the C2H3, C3H11 and C3H12 (p < 0.05, in all cases) (Table 2). The gene discussed is APOE; the disease is familial hyperaldosteronism.