In the peripapillary analysis in the FH+ ApoE ɛ4+ HBP+ group compared with: (i) FH- ApoE ɛ4- HBP-, the second group showed a less significant vascular density in the C1H11 (p < 0.05); (ii) FH+ ApoE ɛ4- HBP-, the second group showed a less significant vascular density in the C1H11 and C2H10 (p < 0.05, in both cases); (iii) FH+ ApoE ɛ4+ HBP-, the second group showed a less significant vascular density in the C1H10, C1H11 and C2H10 (p < 0.05, in all cases) (Table 3). The gene discussed is APOE; the disease is familial hyperaldosteronism.