When we used EA-Tool to compare the vascular density in FH+ ApoE ɛ4- HBP- with: (i) FH+ ApoE ɛ4+ HBP-, the second group showed statistically significantly lower superficial vascular density in the deep vascular plexus and in the C1H9, C1H10, C1H11 and C1H12 (p < 0.05, in all instances) (Table 3). Here, APOE is linked to familial hyperaldosteronism.