When we compared FH- ApoE ɛ4- HCL- with (i) FH- ApoE ɛ4- HCL+, the second group showed statistically significantly higher vascular density in the deep vascular plexus, in the C1H11 and in the C3H9 (p < 0.05, in all cases); (ii) FH+ ApoE ɛ4- HCL+, we found significantly higher vascular density in the deep vascular plexus and in the C1H1, C2H1, C3H1 and C3H2 (p < 0.05, in all cases); (iii) FH+ ApoE ɛ4+ HCL-, we found significant vascular density changes in the superficial vascular plexus and in the C2H11 and C3H4 (p < 0.05, in all cases) (Table 2). The gene discussed is APOE; the disease is familial hyperaldosteronism.