Moreover, the administration of everolimus in renal and heart transplant patients demonstrated a statistically significant increase in PCSK9 levels [23,24], especially in patients with the mTORC1 rs2295080G polymorphism (p = 0.006) [24]: although it was not correlated with an increase in LDL levels, as the authors suggested, PCSK9 level elevation should represent an independent risk factor for the onset of CVD [109] or graft vasculopathy [23]. Here, PCSK9 is linked to vascular disorder.