INS and diabetes mellitus: In the AMD Annals Initiative Study, Russo et al. investigated the contribution of high TG and/or low HDL-C to the residual risk for DCKD in 15.362 patients with T2DM attending diabetes centers throughout Italy over a period of four years; most of the patients were on anti-diabetic (oral agents and/or insulin), lipid-lowering (statins, fibrates), and anti-hypertensive medications, and aspirin.