Women with lower adiponectin levels had a 55% increased risk of developing preeclampsia (AOR 1.55, 95% CI 1.06, 2.26) and greater than 2-fold increased risk for GDM (AOR 2.36, 95% CI 1.46, 3.79) when analyzed without adjustment for pre-pregnancy BMI. The gene discussed is ADIPOQ; the disease is gestational diabetes.