The IFN family of cytokines (α, β, ε, κ, τ, δ, ζ, ω, ν, γ, λ), their signaling protein activators, and their effector proteins are collectively known as interferon signature, and are described as key mediators of SLE and LN [29,30]. The gene discussed is IFNA1; the disease is systemic lupus erythematosus.