CRP and bacterial infectious disease: However, in the conundrum of inflammatory marker cut-offs, procalcitonin was the one that lead to the most divided opinions, with some doctors guiding the prescriptions of antibiotics based on their value and previous thresholds, while others put it quite in the same place with the CRP levels, considering that higher cut-off values would be more appropriate, even though, before COVID-19, procalcitonin represented a strong argument in favor of bacterial infections, as it is shown below.