Authors analyzed 31 pts out of 294 operated for BC and who developed a histologically verified thyroid disease at least 1 year later breast surgery (10.5%). Thyroidectomy was performed in 29/31 BC pts. Malignant thyroid disease as second primary tumor was found in 34.5% of pts (5 macro-PTC, 3 micro-PTC and 2 FTC). Seven of these 10 thyroid malignancies were both ER and PR positive. The most frequent final diagnosis (51.7%) was colloid cystic MNG, while HT was found in 7 pts (24.1%). This evidence concerns the gene PGR and thyroid cancer, nonmedullary, 2.