CHEK2 and breast cancer: Among 10,792 BC pts, 53 pts (0.49%) developed TC during a mean follow-up period of 14 years, that is 4 times greater than the expected number of 12 pts. TC histology was available for 50 pts, and it was PTC (n = 45 [90% of 50]), FTC (n = 3 [6%]) or medullary TC (n = 2 [4%]). The median time from BC diagnosis to TC diagnosis was 6.3 years. A total of 914 BC pts (8.3%) carried a CHEK2 mutation while 502 BC pts (4.6%) carried a BRCA1 mutation. Among the 914 women with a CHEK2 mutation, there were 10 TC observed, but only one was expected.