Therefore, several knockout or transgenic mouse models, such as insulin-gastrin (INS-GAS) [44], interferon gamma (IFN-γ), tumor necrosis factor alpha (TNF-α) knockout [45], interleukin (IL)-1 beta (IL-1β) transgenic [46], IL-10 knockout [47], Fas antigen transgenic [48], p27-deficient [49], and cytotoxin-associated gene A (CagA)-transgenic mice [50], are prone to develop gastric cancer when given a high-salt diet or chemical carcinogens of H. pylori infection [43,51]. This evidence concerns the gene TNF and gastric cancer.