Of the whole study population, one patient had a family member with a history of TMA and this patient also had a disease-causing heterozygous mutation of factor H. Total 4 (13.3%) patients had a family history of an unknown kidney disease, of which one patient had a heterozygous mutation in the C3 gene and a heterozygous risk haplotype in MCP. This evidence concerns the gene C3 and kidney disorder.