RAF1 and Netherton syndrome: Noonan Syndrome (NS) is a multisystem disorder, caused by dysregulation of the Ras/MAPK signaling pathway [1,2,3] and 19 Pathogenic variants in genes encoding for components of this pathway have been identified and linked to NS, of which PTPN11, SOS1, RAF1 and RIT1 are the most prevalent [4,5,6].