Moreover, it has been reported to be associated with tumor proliferation [15], epithelial–mesenchymal transition (EMT), and inflammatory signals, such as tumor necrosis factor-a (TNF-a), nuclear factor-kappa B(NF-κB), and heparin-binding epidermal growth factor-like growth factor (HB-EGF) [11]. Here, HBEGF is linked to neoplasm.