Moreover, FGFR3 and FGFR4 showed a significant upregulation in advanced stages of HCC patients (Figure S1C,D).The results from three independent cohorts suggested a strong positive correlation between FGFR2 expression and HCV-positive cirrhosis patients as well as HCV-positive HCC patients. This evidence concerns the gene FGFR4 and hepatocellular carcinoma.