The genetic linkage of the ABO locus with low-density lipoprotein, type 2 diabetes, and inflammatory risk biomarkers, such as E-selectin, P-selectin, and intercellular adhesion molecules, could at least partially explain the higher prevalence of cardiovascular disease and/or adverse lipid profiles in patients with a non-O blood type [27,28,29]. This evidence concerns the gene SELE and type 2 diabetes mellitus.