The key strength of our project relies in the performing of an in-depth immunological analysis on SCD in a pediatric context, comprehensive of all T- and (almost) all B-cell subsets, including also IgG, IgA, IgM and IgE, in an attempt to attribute clinical implications both to SCD baseline and to HU-related immunological parameters. This evidence concerns the gene IGHE and Schnyder corneal dystrophy.