Another issue worthy of further discussion, but not investigated in our study, regards the assessment in the SCD group of splenic function through Howell–Jolly body or pitted erythrocyte detection in a peripheral blood smear, as well as through an imaging-guided detection of spleen size, radionuclide uptake and major thromboembolic events involving celiac/splenic vessels or through CD19+ IgM memory B-cell count by venous blood sampling [2,3,4,43]. This evidence concerns the gene CD40LG and Schnyder corneal dystrophy.