Within a large case–control study that included six prospective cohorts and 565 SCD cases (as compared to 1090 matched controls), cTNI, NT-proBNP, high-density lipoprotein cholesterol ratio and high-sensitivity C-reactive protein were especially associated with an increased risk of SCD at 11 years [6]. The gene discussed is NPPB; the disease is Schnyder corneal dystrophy.