The courses of patients #1 and #6 were much more ominous, which might be caused by too much immunosuppression (two doses of rituximab as shown in Table 2), resulting in polyoma viral infection (at 4.5 months in patient #1 and 2 months in patient #6, with (at 4 months in patient #6) or without polyoma nephropathy (designated at T2 and T3 in Table 2), ABO incompatibility, and presence of PRA as well as high HLA mismatch (Table 1). The gene discussed is S100A6; the disease is viral infectious disease.