In this study, after an initial experience reviewing the current literature on the available biomarkers for characterizing LN [38], we chose to focus our attention on renal fibrosis and test the unknown potential of DKK3, which is emerging as a marker of tissue fibrosis in other diseases and that might represent a further prognostic tool in the management of patients with LN. The gene discussed is DKK3; the disease is lobular neoplasia.