Given this and DKK3’s role in kidney and B cell modulation and tissue regeneration, we aimed to prospectively investigate the value of serum levels of DKK3 in SLE patients with and without LN to assess DKK3 changes in relation to kidney function, rate of flares, and the degree of interstitial fibrosis observed at the kidney biopsy. The gene discussed is DKK3; the disease is lobular neoplasia.