When comparing baseline values of serum creatinine in SLE patients (dichotomized as abnormal > 1.1 mg/dL, approximation needed considering the small sample size) and nephrotic range proteinuria, DDK3 levels > 75th percentile resulted in having a better diagnostic accuracy for the diagnosis of LN (DKK3: AUC of 94%, sensitivity of 97%, specificity of 88%; sCr: AUC of 55%, sensitivity of 77%, and specificity of 51%; nephrotic range proteinuria: AUC of 68%, sensitivity of 88.3%, and specificity of 57%). The gene discussed is DKK3; the disease is lobular neoplasia.