When focusing on patients with biopsy-proven LN, crude logistic regression analysis showed that DKK3 levels were associated with prevalent chronic kidney diseases (OR: 4.31 [2.01–6.61] per DKK3 doubling, p < 0.01), higher chronicity index at the biopsy (OR: 1.75 [1.51–2.77] per DKK3 doubling, p < 0.01), and rate of flares (OR: 1.45 [1.1–5.71] per DKK3 doubling, p = 0.044). Here, DKK3 is linked to chronic kidney disease.