CRP and Increased total leukocyte count: Our data showed that patients who required oxygen therapy during hospitalization more often had WBC aberration with leucopenia or leukocytosis (white blood cell count less than 4 × 109/L or greater than 11 × 109/L, respectively), lymphopenia, higher D-Dimer and CRP, hyponatremia, and metabolic acidosis on admission compared to those who did not require oxygen therapy (Table 2).