Altogether, our findings indicate that high cytokine levels, i.e., IL-6, IL-8, and G-CSF, between day 7 and day 14 of hospitalization, in patients with SARS-CoV-2-induced ARDS on glucocorticoid treatment and NIV, correlate with NIV failure and with a need for IMV. Here, CXCL8 is linked to acute respiratory distress syndrome.