SPP1 and osteoporosis: Moreover, they were also involved in enhancing expression of genes associated with bone remodeling, such as osteopontin (OPN), osteocalcin (OCL) or alkaline phosphatase (ALP), that suggest that PRHD and its modification could be used as a potential agent in the treatment of osteoporosis in the future, although further studies on animals are strongly recommended to confirm the results obtained on the culture cells.