Novel multifunctional polymeric nanoparticle contrast agent made of (anti–VEGF PLA–PEG–PLL–Gd NP), simultaneously modified with gadolinium–diethylenetriamine–pentaacetic acid (Gd–DTPA) and anti–vascular endothelial growth factor (VEGF) antibody has been developed for delivery of Gd–DTPA to the tumor area and for achieving the early diagnosis of hepatocellular carcinoma [12]. This evidence concerns the gene VEGFA and hepatocellular carcinoma.