Given that microglia express alpha-CamKII [59,60], we hypothesize that, in the absence of the inhibitory role of gonadal hormones on neuroinflammation, the conditional deletion of the Npy1r gene in microglia results in the activation and proliferation of microglia and, in turn, in the obesity observed in SD- and HFD-fed Npy1rrfb ovx females. This evidence concerns the gene NPY1R and Obesity.