Since the SAveRUNNER/GSEA drug candidates rupatadine, diphenhydramine, dimetindene, butriptyline, clomipramine, epinastine, cyproheptadine, and trazodone share antagonistic actions at histamine H1 receptor, by immunohistochemistry we analyzed the presence of this receptor in the parenchyma of frontal cortex from 5 neuropathological confirmed cases of SPMS and 2 patients who died by non-neurological diseases (Table 1). Here, HRH1 is linked to secondary progressive multiple sclerosis.