2. Adult-Onset Leukodystrophy with Axonal Spheroids and Pigmented Glia (POLD, HDLS, ALSP): CRP Linked to Mutations in CSF1R, and LKENP (Leukoencephalopathy, Progressive with Ovarian Failure) Linked to Heterozygous Mutations in AARS2. The gene discussed is AARS2; the disease is leukodystrophy.