Recently, a large-scale study of 799 complete mitogenomes from more than 100 breeds identified two distinct mutations, both associated with point mutations in the mitogenome that are also present in humans (C4171A in the ND1 gene and T10663C in the ND4L gene) and linked to LHON [14]. The gene discussed is MT-ND4L; the disease is Leber hereditary optic neuropathy.